Efficacy and safety of varenicline and bupropion, in combination and alone, for alcohol use disorder: a randomized, double-blind, placebo-controlled multicentre trial

Efficacy and safety of varenicline and bupropion, in combination and alone, for alcohol use disorder: a randomized, double-blind, placebo-controlled multicentre trial.

Bo Söderpalm | Helga Lidö | Johan Franck | Anders Håkansson | Daniel Lindqvist | Markus Heilig | et al.

THE LANCET Regional Health – Europe Volume 54 101310July 2025 https://www.thelancet.com/journals/lanepe/home  © 2025 The Author(s). Published by Elsevier Ltd. DOI: 10.1016/j.lanepe.2025.101310 

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Combined administration of varenicline and bupropion produces additive effects on accumbal dopamine and abolishes the alcohol deprivation effect in ratsPublication